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OLEH V. LUSHCHAK, PhD, Assistant Professor


ADDRESS
Department of Biochemistry and Biotechnology, Natural Sciences Institute, Vasyl Stefanyk Precarpathian National University, 57 Shevchenko str., Ivano-Frankivsk, 76018, Ukraine
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PERSONAL
Ukrainian, male, born May 22, 1983.
Home address: 16 Stefanyka Str., Lysets, Ivano-Frankivsk Distr., 77455, Ukraine
Languages – English, Ukrainian, Russian, German

 

EDUCATION
2000-2005 – Student in Department of Biochemistry and Biotechnology, Natural Sciences Institute,
Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine
2004 – Bachelor’s degree in Biochemistry
2005 – Master’s degree in Biochemistry
2005-2008 – Ph.D. student Department of Biochemistry and Biotechnology
2009 – PhD degree in Biochemistry

 

RESEARCH EXPERIENCE AND PRACTICAL TRAININGS
2000-9 – Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
2002 – INTAS fellow “Growth dynamics in molluscs in natural environment”, Institute of Marine Biology, Kotor, Montenegro.
2003 – DAAD research fellow “Regulation of NADH oscillations in yeast”, Department of Biophysics, Otto-von-Gurike University, Magdeburg, Germany.
2009 – JEB research fellow “Rhodiola rosea as learning enhancer in D. melanogaster”, Department of Neurobiology and Genetics, University of Wurzburg, Wurzburg, Germany.
2009 – Visiting scientist “Mechanisms of lifespan extension by dietary restriction in D. melanogaster”, Buck Institute for Age Research, Novato, CA, USA.
2010 – Visiting scientist “Modulation of fly learning by natural chemicals”, Department of Neurobiology and Genetics, University of Wurzburg, Wurzburg, Germany.
2011-13 – Postdoc position supported by Carl Trygger Foundation “Food odors trigger an endocrine response that affects appetite, metabolism and lifespan”, Department of Zoology, Stockholm University, Stockholm, Sweden.
2012 – Visiting scientist “Mechanisms of lifespan and metabolism regulation by mitochondria”, Institute of Biomedical Technology, University of Tampere, Tampere, Finland.
2013-2014 - Visiting scientist “Nutrition and tissue homeostasis in fruit fly gut”, DKFZ-ZMBH Alliance, Heidelberg, Germany.
2015-2016 – Guest scientist “Epigenetic regulation of metabolism” Max-Planck-Institute of Immunology and Epigenetics, Freiburg, Germany.
2014-present – Head of laboratory “Aging and age-related disease”, Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.

 

AWARDS AND GRANTS
2015 – Albert Renold Fellowship from EFSD to work in the lab of Andrew Pospisilik.
2014-16 – Stipend from Cabinet of Ministers of Ukraine
2013 – Platon Kostyuk Award from Ukrainian Society for Neuroscience (Kyiv, Ukraine).
2013 – Best Young Scientist of Vasyl Stefanyk Precarpathian National University.
2008 – Travel Fellowship grant from Journal of Experimental Biology to visit Dr Bertram Gerber.
2008 – Participation in 12th Yeast Congress, Kyiv, Ukraine. Was selected to oral presentation of the results. Participation fee was covered by FEMS.
2007 – Organiser and participant in international Workshop: Molecular physiology of membrane transport and cellular signaling, Yaremche, Ukraine.
2007-8 – Project leader, Molecular mechanisms of yeast Saccharomyces cerevisiae response to carbonate ions. State Fund of Fundamental Investigations of Ukrainian Ministry of Education and Science.
2007 – First place for the best oral presentation in young scientists' conference "Youth and progress in biology" (Lviv, Ukraine).
2006 – Participation in International Free Radical Summer School 2006: Biomarkers of oxidative stress and responses, Spetses Island, Greece. Participation fee and travel grants were provided by FEBS.
2006 – Award for the best poster in "IX Congress of Ukrainian Biochemical Society".
2005 – Second place for the best oral presentation in young scientists' conference "Youth and progress in biology" (Lviv, Ukraine).
2003 – DAAD grant for student exchange, training in Biophysics, Otto-von-Gurike University, Magdeburg, Germany.
2002 – INTAS funded program for student exchange, training in Marine Biology, Institute of Marine Biology, Kotor, Montenegro.

 

TEACHING
Assistant Professor in Biochemistry
Courses: Molecular Biology, Introduction into Experimental Biology, Analytical Biochemistry, Basic Principles of Scientific Research

 

SUPERVISOR

Co-supervisor for PhD students:
2009-2012 – Bohdana Rovenko
2010-2013 – Lozinskyi Olexandr
2011 – 2014 Yurkevych Ihor, Perkhulyn Natalia
2013 – Stril’bytska Olha, Semanjuk Uliana
2014 – Burdyljuk Nadia

 

REVIEWER
Aging Cell, Journal of Gerontology, Experimental Gerontology, Journal of Comparative Physiology, PLoS One, PloS Genetics, Redox Reports, Proceedings of the Royal Society, Cancer Research, Entomologia Experimentalis et Applicata.

 

CURRENT AREAS OF RESEARCH
- Nutrition and metabolism regulation;
- Signaling in regulation of aging;
- Nutrition, mitochondria and ROS metabolism;
- Stem cells and aging;
- Signaling pathways in tissue homeostasis;
- Nutrition and stem cell metabolism;
- ROS as signaling molecules;
- Epigenetic regulation in aging and metabolism.

 

HONOURS
2012 – Who's Who in the World
2012 – 2000 Outstanding Intellectuals of the 21st Century 2012
2014 – 42nd in Scopus based ranking of Ukrainian scientist in “Medicine and Natural sciences”
2015 – 8th in Scopus based ranking of Ukrainian young scientists

 

EDITORIAL BOARDS
Biochemistry and Physiology

 

MEMBERSHIP
Ukrainian Biochemical Society
European Foundation for the Study of Diabetes

 

PUBLICATIONS
* - corresponding author
** - co-corresponding author

Articles

47. Lushchak O*., Gospodaryov D., Yurkevych I. Oxidized lipids did not reduce lifespan in the fruit fly, Drosophila melanogaster. Arch. Insect Biochem. Physiol., 2016, 91, 52-63.
46. Rovenko B., Kubrak O., Gospodaryov D., Perkhulyn N., Yurkevych I., Sanz A., Lushchak O**., Lushchak V. High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster. J. Insect Physiol., 2015, 79, 42-54.
45. Rovenko B., Kubrak O., Gospodaryov D., Yurkevych I., Sanz A., Lushchak O**., Lushchak V. Restriction in glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster. Comp. Biochem. Physiol., 2015, 187, 27-39.
44. Lushchak O., Carlsson M., Nässel D. Food odors trigger an endocrine response that affects food ingestion and metabolism. Cell. Mol. Life Sci., 2015, 72, 3143–3155.
43. Perkhulyn N., Rovenko B., Zvarych T., Lushchak O., Storey J., Storey K., Lushchak V. Sodium chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila
melanogaster. Comp. Biochem. Physiol., 2015, 167, 74-80.
42. Rovenko B., Perkhulyn N., Gospodaryov D., Sanz A., Lushchak O**., Lushchak V. High fructose consumption rather than glucose promotes diet-induced obese phenotype in Drosophila melanogaster. Comp. Biochem. Physiol., 2015, 180, 75-85.
41. Gospodaryov D., Lushchak O., Rovenko B., Perkhulyn N., Gerards M., Tuomela T., Jacobs H. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochem. Biophys. Acta, 2014, 1837(11), 1861-1869.
40. Luo J., Lushchak O., Goergen P., Williams M., Nässel D. Drosophila insulin-producing cells are differently modulated by serotonin and octopamine receptors and affect aggressive behaviour. PLoS one, 2014, 9(6), e99732.
39. Rovenko B., Perkhulyn N., Lushchak O., Storey J., Storey K., Lushchak V. Molybdate partially mimics insulin-promoted metabolic effects in Drosophila melanogaster. Comp. Biochem. Physiol., 2014, 165, 76-82.
38. Lushchak O*., Gospodaryov D., Rovenko B., Yurkevych I., Perkhulyn N., Lushchak V. Specific dietary carbohydrates differentially influence the lifespan and fecundity of Drosophila melanogaster. J Gerontol A Biol Sci Med Sci., 2014, 69(1), 3-12.
37. Rovenko B., Lushchak V., Lushchak O. Carbohydrate restriction in the larval diet causes oxidative stress in adult insects of Drosophila melanogaster. Ukr. Biochem. J., 2013, 85(5), 61-72.
36. Lozinsky O., Lushchak O., Storey J., Storey K., Lushchak V. The mitochondrial uncoupler 2,4-dinitrophenol attenuates sodium nitroprusside-induced toxicity in Drosophila melanogaster: Potential involvement of free radicals. Comp. Biochem. Physiol., 2013, 158(4), 244-52.
35. Lozinsky O., Lushchak O., Lushchak V. 2,4-dinitrophenol partially alleviates ferrocyanide induced toxicity in Drosophila melanogaster. Arch. Insect Biochem. Physiol., 2013, 84(3), 157-73.
34. Gospodaryov D., Yurkevych I., Lushchak O**., Lushchak V. Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. Longevity & Healthspan, 2013, 2:12.
33. Lozinsky O., Lushchak O., Kryshchuk N., Shchypanska N., Riabkina A., Skarbek S., Maksymiv I., Storey J., Storey K., Lushchak V. S-nitrosoglutathione-induced toxicity in Drosophila melanogaster: Delayed pupation and induced mild oxidative/nitrosative stress in eclosed flies. Comp. Biochem. Physiol., 2013, 164(1), 162-170.
32. Kapan N., Lushchak O., Luo J., Nässel D. Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin. Cell. Mol. Life Sci., 2012, 69(23), 4051-4066.
31. Rovenko B., Lushchak O*., Lozinsky O., Kubrak O., Lushchak V. Mild oxidative stress in fruit fly Drosophila melanogaster induced by sucrose. Ukr. Biochem. J., 2012, 84 (5), 97-105.
30. Lozinsky O., Lushchak O., Lushchak V. Sodium nitroprusside toxicity in Drosophila melanogaster: delayed pupation, reduced adult emergence, and induced oxidative/nitrosative stress in eclosed flies. Arch. Insect Biochem. Physiol., 2012, 80(3), 166-185.
29. Lushchak O*., Gospodaryov D., Rovenko B., Glovyak A., Yurkevych I., Klyuba V., Shcherbij M., Lushchak V. Balance between macronutrients affects lifespan and functional senescence in fruit fly Drosophila melanogaster. J. Gerontol. A Biol. Sci., 2012, 67(2), 118-125.
28. Lushchak O., Rovenko B., Gospodaryov D., Lushchak V. Drosophila melanogaster larvae fed by glucose and fructose demonstrate difference in oxidative stress markers and antioxidant enzymes of adult flies. Comp. Biochem. Physiol., 2011, 160(1), 27-34.
27. Kubrak O., Lushchak O., Lushchak J., Torous I., Storey J., Storey K., Lushchak V. Chromium effects on free radical processes in goldfish tissues: Comparison of Cr(III) and Cr(VI) exposures on oxidative stress markers, glutathione status and antioxidant enzymes. Comp. Biochem. Physiol., 2010, 152, 360-370.
26. Lushchak O., Inoue Y., Lushchak V. Saccharomyces cerevisiae exhibits a Yap1-mediated adaptive response to SNP-induced stress. Biochemistry (Moscow), 2010, 75(5), 629-635.
25. Lushchak O., Bahniukova T., Lushchak V. Activation of enzymes of soxRS-regulon by hydrogen peroxide in Escherichia coli. Microbiol. J., 2009, 71 (1), 22-27
24. Lushchak O., Bayliak M., Korobova O., Levine R., Lushchak V. Buffer modulation of menadione-induced oxidative stress in Saccharomyces cerevisiae. Redox Report, 2009, 14(5), 214-220.
23. Lushchak O., Kubrak O., Storey J., Storey K., Lushchak V. Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissues. Chemosphere, 2009, 76 (7), 932-937.
22. Lushchak O., Kubrak O., Lozinsky O., Storey J., Storey K., Lushchak V. Chromium(III) induces oxidative stress in goldfish liver and kidney. Aquat. Toxic., 2009, 93, 45–52.
21. Lushchak O., Lushchak V. Possible pathways involved in activation of catalase and superoxide dismutase in yeast S. сerevisiae treated with sodium nitroprusside. Ukr. Biochem. J., 2009, 81 (2), 26-31.
20. Lushchak O., Kubrak O., Torous I., Nazarchuk T., Storey K., Lushchak V. Trivalent chromium induces oxidative stress in goldfish brain. Chemosphere, 2009, 75, 56-62.
19. Semchuk N., Lushchak O., Nazarchuk T., Falk J., Krupinska K., Lushchak V. Inactivation of genes, encoding tocopherol biosynthesis pathways enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana. Plant Physiol. Biochem., 2009, 47(5), 384-390.
18. Lushchak O., Nykorak M., Ohdat T., Inoue Y., Lushchak V. Inactivation of superoxide dismutase incoding genes modifies yeast cell response to S-nitrosoglutathione induced stress. Biochemistry (Moscow), 2009, 74(4), 550-557.
17. Lushchak O., Lushchak V. Catalase modifies yeast Saccharomyces cerevisiae response toward S-nitrosoglutathione-induced stress. Redox Report, 2008, 13(6), 283-291.
16. Semchuk N., Lushchak O., Falk J., Krupinska K., Lushchak V. Effects of VTE1 and VTE4 gene inactivation of salt stress response in Arabidopsis thaliana. Ukr. Biochem. J., 2008, 80 (3), 48-54.
15. Lushchak O., Kubrak O., Nykorak M., Storey K., Lushchak V. The effect of potassium dichromate on free radical processes in goldfish: Possible protective role of glutathione. Aquat. Toxic., 2008, 87, 108–114.
14. Lushchak O., Lushchak V. Sodium nitroprusside induces mild oxidative stress in Saccharomyces cerevisiae. Redox Report, 2008, 13(4), 144-152.
13. Lushchak O., Lozinsky O., Nazarchuk T., Lushchak V. S-nitrosoglutathione induces nitrosative stress in yeast: modified role of catalase. Ukr. Biochem. J., 2008, 80 (2), 84-91.
12. Kubrak O., Lushchak O., Lushchak V. Comparative characteristics of lactate dehydrogenase from the liver and white muscles of common carp (Cyprinus carpio). Ukr. Biochem. J., 2008, 80 (4), 35-41.
11. Lushchak O., Semchyshyn H., Lushchak V. Growth on ethanol results in coordinated yeast S. cerevisiae cell response on inactivation of genes encoding superoxide dismutases. Redox Report, 2007, 12(4), 181-188.
10. Lushchak V., Bagnyukova T., Lushchak O., Storey J., Storey K. Superoxide dismutase inhibition by diethyldithiocarbamate induces oxidative stress in goldfish brain. Chem.-Biol. Interact., 2007, 170(1), 1-8.
9. Bagnyukova T., Lushchak O., Storey K., Lushchak V., Oxidative stress and antioxidant defense responses by goldfish tissues to acute change of temperature from 3 to 23ºC. J. Thermal Biol., 2007, 32, 227–234
8. Mandryk S., Lushchak O., Semchyshyn H., Lushchak V. Role of Cu,Zn- and Mn-containing superoxide dismutases in yeast cell during growth on ethanol. Microbiol. J. (Ukr), 2007, 69(2), 35-42.
7. Lushchak O*., Muller S., Mair T. Synchronization of NADH oscillations in yeasts Saccharomyces cerevisiae and S. carlsbergensis. Ukr. Biochem. J., 2006, 78 (5), 12-18.
6. Lushchak V., Semchyshyn H., Mandryk S., Lushchak O. Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions. Arch. Biochem. Biophys., 2005, 441, 35-40.
5. Lushchak V., Semchyshyn H., Lushchak O., Mandryk S. Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells. Biochem. Biophys. Res. Commun., 2005, 338, 1739-1744.
4. Lushchak V., Bagnyukova T., Husak V., Luzhna L., Lushchak O., Storey K. Hyperoxia results in transient oxidative stress and an adaptive response by antioxidant enzymes in goldfish tissues. Int. J. Biochem. Cell Biol., 2005, 37, 1670-1680.
3. Lushchak V., Bagnyukova T., Lushchak O., Storey J., Storey K. Hypoxia and recovery perturb free radical processes and antioxidant potential in common carp (Cyprinus carpio). Int. J. Biochem. Cell Biol., 2005, 37, 1319-1330.
2. Lushchak V., Bagnyukova T., Lushchak O. Indices of oxidative stress. 1. TBA-reactive substances and carbonylproteins. Ukr. Biochem. J., 2004, 76 (3), 136-141.
1. Lushchak O., Bagnyukova T., Lushchak V. The effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase of two frog species - Rana ridibunda and R. esculenta. Ukr. Biochem. J., 2003, 75 (4), 45-50.

Reviews and book chapters

3. Lushchak. O., Piroddi M., Galli F., Lushchak V. Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling and metabolism of reactive oxygen species. Redox Report, 2014, 19 (1), 8-15.
2. Nässel D., Kubrak O., Liu Y., Luo J., Lushchak O. Factors that regulate insulin producing cells and their output in Drosophila. Front. Physiol., 2013, 4, art. 252.
1. Lushchak, V. I., Semchyshyn, H. M. and Lushchak, O. V. (2011) The Classic Methods to Measure Oxidative Damage: Lipid Peroxides, Thiobarbituric-Acid Reactive Substances, and Protein Carbonyls, in Oxidative Stress in Aquatic Ecosystems (eds D. Abele, J. P. Vázquez-Medina and T. Zenteno-Savín), John Wiley & Sons, Ltd, Chichester, UK.

 

BIBLIOMETRICS
February 2016: Scopus h-index – 15, Citations – 837; Google Scholar h-index – 19, Citations – 1126. Total impact factor – 101.