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Maria Bayliak (Read more)

Year of admission: 2014
Title of Doctorate thesis: Using of natural products as adaptogens and anti-aging agents
Specialty: 03.00.05 – Biochemistry
Supervisor: Prof., D.Sci. Volodymyr Lushchak.

Annotation. During last decades, researchers have been actively working how to increase the adaptive capacity of the organism and thus to improve human health and to prolong lifespan. One of such research areas is searching natural substances which can be potential stimulators of endogenous defensive mechanisms with numerous beneficial health effects and with the absence or low expression of side effects. It has been found that some plant extracts of herbs and other natural compounds (organic acids, polyphenols, vitamins, etc.) posses these properties. Different model objects, from unicellular organisms to mammals, are used to study the mechanisms of action of these compounds. This work is focused on the study of effects of plant extracts (Rhodiola rosea, Gentiana lutea, Rosa canina), quercetin, arginine, alpha ketoglutarate and other natural keto acids on adaptive potential, metabolism and lifespan of baker's yeast Saccharomyces cerevisiae and fruit fly Drosophila melanogaster, which are popular models for the study of many biological phenomena.  



Oleh Lushchak (Read more)

Year of admission: 2015
Title of Doctorate thesis: Interrelation between lifespan, fecundity and metabolism 
Specialty: 03.00.05 – Biochemistry
Supervisor: Prof., D.Sci. Volodymyr Lushchak.

Annotation. Nutrition is an important physiological train for every alive organism. It influences the lifespan, metabolism, reproduction and others. However, these factors together with hormonal regulation affect nutrition to form the network of regulatory mechanism to form proper response to macronutrient availability. Unbalanced nutrition may cause the changes in metabolism to induce development of complication like obesity, diabetes or cancer. The aim of the work is to study the molecular mechanisms to regulate nutrition, lifespan and metabolism in response to diet. Additionally, evolutional aspects of adaptation to unbalanced diet and the role of TOR and IIS/IGF pathways will be analyzed.

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