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                                Postgraduate study                                prapor ua

 

 Сорочинська (Витвицька) Оксана

 Sorochynska (Vytvytska) Oksana

Year of admission:  2015
Title of PhD thesis:  Development of optimal methods for purifying immunoglobulin G.
Specialty: 03.00.20 – Biotechnology
Supervisor:  Prof., D.Sci Volodymyr Lushchak.

Аnnotation to the theme:  Immunoglobulins (Igs) are a group of glycoproteins which are contained in the blood plasma (antibodies) and on the surface of certain cells of immune system (immunoglobulin receptors). Serum IgG is the major class of antibody in humans, it constitutes 70-75 % of all immunoglobulins. IgG play an important role at the primary and the secondary immune response. Immunoglobulin G is responsible for binding to the antigen and provides some effector functions, complement activation, binding to cells. By the presence of specific IgG in human plasma it’s possible to conclude about the presence of the pathogen in the body or about infection. Consequently, diagnosis of many infections are based on the detection of specific IgG in human serum.


 Манюх Оксана

 Manyuh Oksana

Year of admission: 2015
Title of PhD thesis: Optimization of food for the mice in order to get the maximum output of ascites.
Specialty: 03.00.20 – Biotechnology
Supervisor:  Prof., D.Sci Volodymyr Lushchak.

Аnnotation to the theme:  At the present stage of science and medicine developments the question arises about the artificial creation of hybrid. Hybridoma is an artificial hybrid line of cells derived by fusion of B cells, which produce antibodies with myeloma cells. Hybridomas are widely used for getting the monoclonal antibodies, which are produced by immune cells, belong to one and the same cellular circle, originate from a single epitope. Monoclonal antibodies, in their turn, are used to the analysis of the immune response, the embryonic development and the antigens complex mixtures analyses. They are also applied to the localization of tumors, the diagnosis of viral and bacterial diseases, the detection of worms, the immune-enzyme and food quality analyses. The aim of this work is to maximize the output of hybridoma culture (ascites) by proper selection of diet for mice. 

 Лилик Марія

 Lylyk Mariia

Year of admission:  2015
Title of PhD thesis:  Physiological and biochemical peculiarities of the fruit fly Drosophila melanogaster reared on food with alpha-ketoglutarate.
Specialty: 03.00.04 – Biochemistry
Supervisor:  Assoc. Prof. ,  Ph. D., Bayliak Mariia.

Аnnotation to the theme: Alpha-ketoglutarate (AKG) is an intermediate of Krebs cycle, which bridges energy production with amino acid metabolism. In last years, many favorable effects of AKG as a dietary supplement have been reported. In particular, AKG was found to beneficially influence protein/amino acid metabolism, redox homeostasis, lifespan, age-related functional decline and certain metabolic disturbances. In Drosophila, these processes are similar to those in humans. In this study, D. melanogaster is used as a model object to reveal new beneficial effects of dietary AKG. The research is focused on implication of AKG in free radical-related processes and protein/ amino acid metabolism in D. melanogaster flies of different ages.

 Burdylyuk  Nadia

Burdylyuk  Nadia 

Year of admission: 2014

Title of PhD thesisDrosophila melanogaster as a model for studying of the aging mechanisms and associated pathologies.

Specialty03.00.04 – Biochemistry

Supervisor: Prof., D.Sci Volodymyr Lushchak.

Annotation to the themeToday, obesity is very prevalent problem among young people, and is the main risk factor for the development of metabolic syndrome and related diseases. Excessive intake of nutrients, especially carbohydrates, contributes to obesity. It may be one of the causes of insulin resistance which result in diabetes. Recent studies have shown that there is very similar regulatory mechanisms in Drosophila and humans. The aim of the study is to develop a model of fruit fly for studying the mechanisms of obesity and diabetes.

Strilbytska (Bevzyuk) Olha 

Strilbytska (Bevzyuk) Olha


Year of admission: 2013
Title of PhD thesis: Role of TOR and insulin signaling pathways in Drosophila stem and progenitor cells in regulation of metabolism, stress resistance and longevity
Specialty: 03.00.04 – biochemistry
Supervisor: Prof., D.Sci Volodymyr Lushchak
Annotation to the theme: Stem cells are critical to maintain tissue homeostasis in high-turnover tissues and involved in regulation of growth processes. Proliferation of stem and progenitor cells has to be carefully controlled to prevent hyper-proliferative diseases. TOR (target of rapamycin) and insulin signaling in Drosophila stem cells promoting proliferative homeostasis, are expected to be critical for longevity. Our results highlight the importance of the balance between regenerative processes and strategies to prevent hyperproliferative disorders and demonstrate that promoting proliferative homeostasis in aging metazoans is a viable strategy to extend lifespan.

 Васильковська Руслана  

Vasylkovska Ruslana

Year of admission: 2013
Title of PhD thesis: Involvement of antioxidant system in cross-adaptation of yeast Saccharomyces cerevisiae.
Specialty: 03.00.04 – Biochemistry
Supervisor:  Ph.D., Halyna Semchyshyn.

Аnnotation to the theme: The ability of living organisms to cross-adaptation is one of the main conditions for their survival and normal functioning under unfavorable conditions. It is known that stress factors lead to the development of various diseases, metabolic disturbances, and accelerate aging of organisms. However, the molecular mechanisms that underlie these disorders have not been fully studied. In particular little is known about involvement of the antioxidant system in cross-adaptation of organisms. Like mammalian, in yeast aging is associated with the weakening of the functions,of protective systems and increased sensitivity to stress. S. cerevisiae is adequate model system for studying of different molecular mechanisms, because its many of the molecular mechanisms are similar to such in higher eukaryotes.

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